Somatic structural variation and cancer
نویسندگان
چکیده
منابع مشابه
Characterizing complex structural variation in germline and somatic genomes.
Genome structural variation (SV) is a major source of genetic diversity in mammals and a hallmark of cancer. Although SV is typically defined by its canonical forms (duplication, deletion, insertion, inversion and translocation), recent breakpoint mapping studies have revealed a surprising number of 'complex' variants that evade simple classification. Complex SVs are defined by clustered breakp...
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Identification of somatic rearrangements in cancer genomes has accelerated through analysis of high-throughput sequencing data. However, characterization of complex structural alterations and their underlying mechanisms remains inadequate. Here, applying an algorithm to predict structural variations from short reads, we report a comprehensive catalog of somatic structural variations and the mec...
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ژورنال
عنوان ژورنال: Briefings in Functional Genomics
سال: 2015
ISSN: 2041-2649,2041-2657
DOI: 10.1093/bfgp/elv016